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贞芪扶正颗粒辅助治疗宫颈癌的临床观察
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篇名: 贞芪扶正颗粒辅助治疗宫颈癌的临床观察
TITLE:
摘要: 目的:观察贞芪扶正颗粒辅助治疗宫颈癌的疗效和安全性。方法: 86例宫颈癌患者随机分为对照组(43例)和观察组(43例)。对照组患者于化疗前0.5 h分别静脉滴注盐酸苯海拉明注射液20 mg,盐酸格拉司琼葡萄糖注射液5 mg,西咪替丁注射液20 mg,静脉滴注0.5 h后开始化疗:多西他赛注射液40 mg/m2,d1,d8,静脉滴注;注射用顺铂25 mg/m2,d1-3,静脉滴注;21 d为1个周期,共4~6个周期。观察组患者在对照组治疗的基础上口服贞芪扶正颗粒5 g,每日2次。观察两组患者的临床疗效,治疗前后T细胞亚群指标[CD3+、CD4+、CD8+、自然杀伤细胞(NK)]、功能状态(KPS)评分,化疗终止情况、终止时间、化疗次数及毒副反应发生情况。结果:观察组患者总缓解率显著高于对照组,观察组化疗终止患者占比显著少于对照组,化疗终止时间显著短于对照组,化疗次数显著多于对照组,胃肠道反应、贫血、血小板降低、白细胞下降发生率均显著低于对照组,差异均有统计学意义(P<0.05);两组患者肝功能损伤、肾功能损伤、口腔炎发生率比较,差异均无统计学意义(P>0.05)。治疗前,两组患者T细胞亚群指标及KPS评分比较,差异均无统计学意义(P>0.05)。治疗后,观察组患者CD3+、CD4+、NK细胞水平均显著高于同组治疗前及对照组,CD8+水平显著低于同组治疗前及对照组;两组患者KPS评分均显著高于同组治疗前,且观察组显著高于对照组,差异均有统计学意义(P<0.05);对照组患者治疗前后T细胞亚群指标比较,差异均无统计学意义(P>0.05)。结论: 在常规治疗的基础上,贞芪扶正颗粒可提高宫颈癌患者的疗效,改善机体免疫功能,提高生存质量,降低毒副反应。
ABSTRACT: OBJECTIVE: To observe therapeutic efficacy and safety of Zhenqi fuzheng granules in the adjunctive treatment of cervical cancer. METHODS: 86 patients with cervical cancer were randomly divided into control group (43 cases) and observation group (43 cases). Control group was given intravenous dripping of Diphenhydramine hydrochloride injection 20 mg, Granisetron hydrochloride and glucose injection 5 mg, Cimetidine injection 20 mg at 0.5 h before chemotherapy. After 0.5 h of intravenous dripping, the patients received chemotherapy: Docetaxel injection 40 mg/m2, d1, d8, intravenous dripping; Cisplatin for injection 25 mg/m2, d1-3, intravenous dripping; 21 d as a cycle, a total of 4-6 cycles. On the basis of control group, observation group was additionally given Zhenqi fuzheng granules 5 g, twice 2 day. Clinical efficacies of 2 groups were observed as well as T cell subsets indexes [CD3+,CD4+,CD8+,natural killer cell(NK)], KPS scores, termination, terminal time, the times of chemotherapy and the occurrence of toxic reaction before and after treatment. RESULTS: The total remission rate of observation group was significantly higher than that of control group; the proportion of termination of chemotherapy in observation group was significantly lower than control group; terminal time of chemotherapy was significantly shorter than control group; the times of chemotherapy was significantly more than control group; the incidence of gastrointestinal reaction, anemia, thrombocytopenia and leukopenia were significantly lower than control group, with statistical significance (P<0.05). There was no statistical significance in liver function damage, renal function injury and stomatitis between 2 groups (P>0.05). Before treatment, there was no statistical significance in T cell subsets indexes and KPS scores between 2 groups (P>0.05). After treatment, CD3+, CD4+ and NK cells in observation group were significantly higher than before treatment and control group, while CD8+ was significantly lower than before treatment and control group; KPS scores of 2 groups were significantly higher than before, and the observation group was significantly higher than the control group, with statistical significance (P<0.05). There was no statistical significance in T cell subsets indexes of control group before and after treatment (P>0.05). CONCLUSIONS: On the basis of routine treatment, Zhenqi fuzheng granules can improve therapeutic efficacy, immune function and the quality of life, moreover, reduce toxic reaction in patients with cervical cancer.
期刊: 2017年第28卷第9期
编辑: 张海平,赵慧峰,夏红蕾
AUTHORS: ZHANG Haiping,ZHAO Huifeng,XIA Honglei
关键字: 宫颈癌;贞芪扶正颗粒;辅助治疗;化疗;疗效;安全性
KEYWORDS: Cervical cancer; Zhenqi fuzheng granules; Adjunctive treatment; Chemotherapy; Efficacy; Safety
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