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雾化吸入氨溴索联合庆大霉素对食管癌患者术后相关指标的影响
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篇名: 雾化吸入氨溴索联合庆大霉素对食管癌患者术后相关指标的影响
TITLE:
摘要: 目的: 探讨雾化吸入氨溴索联合庆大霉素对食管癌患者术后相关指标的影响。方法:回顾性分析60例食管癌手术后患者资料,根据用药的不同分为对照组(30例)和观察组(30例)。术前3 d,对照组患者静脉滴注5%葡萄糖注射液250 mL,每日2次;观察组患者静脉滴注盐酸氨溴索注射液50 mL,加入5%葡萄糖注射液250 mL中,每日2次;术后,两组患者均给予抗菌药物消炎、镇痛。在此基础上,对照组患者给予硫酸庆大霉素注射液8万单位,加入0.9%氯化钠注射液20 mL中,雾化吸入,每日4次;观察组患者在对照组治疗的基础上给予盐酸氨溴索注射液10 mL,加入0.9%氯化钠注射液20 mL中,雾化吸入,每日4次。两组均连用5 d。观察两组患者术后肺部并发症发生情况,手术前后C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)水平、动脉血氧分压(PaO2)、动脉血氧饱和度(SaO2)、氧合指数[(PaO2/吸氧浓度(FiO2)]及不良反应发生情况。结果:观察组患者术后肺部并发症总发生率显著低于对照组,差异有统计学意义(P<0.05)。术前,两组患者CRP、TNF-α水平、PaO2、SaO2、PaO2/FiO2比较,差异均无统计学意义(P>0.05)。术后,两组患者CRP、TNF-α水平均显著低于同组术前,且观察组显著低于对照组;而两组患者PaO2、SaO2、PaO2/FiO2均显著高于同组术前,且观察组显著高于对照组,差异均有统计学意义(P<0.05)。两组患者用药期间均未见明显不良反应发生。结论:雾化吸入氨溴索联合庆大霉素可降低食管癌患者术后的炎症因子水平,促进呼吸功能恢复,且并未增加不良反应的发生。
ABSTRACT: OBJECTIVE: To investigate the effects of aerosol inhalation of ambroxol combined with gentamicin on postoperative related indexes of esophageal cancer patients. METHODS: 60 patients underwent esophageal cancer operation were retrospective analyzed and divided into control group (30 cases) and observation group (30 cases) according to drug use. Three days before surgery, control group was given 5% Glucose injection 250 mL intravenously, twice a day; observation group was given Ambroxol hydrochloride injection 50 mL added into 5% Glucose injection 250 mL intravenously, twice a day. After operation, both groups were given anti-inflammatory and analgesic drugs. Control group was additionally given aerosol inhalation of Gentamicin sulfate injection 80 000 units added into 0.9% Sodium chloride injection 20 mL, 4 times a day. Observation group was additionally given aerosol inhalation of Ambroxol hydrochloride injection 10 mL added into 0.9% Sodium chloride injection 20 mL, 4 times a day, on the basis of control group. Both groups were treated for 5 days. The occurrence of postoperative pulmonary complications were compared between 2 groups. The levels of CRP, TNF-α, PaO2, SaO2, oxygenation index (PaO2/FiO2), the occurrence of ADR were observed before and after operation. RESULTS: The total incidence of postoperative pulmonary complications in observation group was significantly lower than control group, with statistical significance (P<0.05). Before operation, there was no statistical significance in the levels of CRP, TNF-α, PaO2, SaO2 and PaO2/FiO2 between 2 groups (P>0.05). After operation, the levels of CRP and TNF-α in 2 groups were significantly lower than before operation; the observation group was significantly lower than the control group. PaO2,SaO2 and PaO2/FiO2 of 2 groups were significantly higher than before operation; the observation group was significantly higher than the control group, with statistical significance (P<0.05). No obvious ADR was found in 2 groups during medication. CONCLUSIONS: The aerosol inhalation of ambroxol combined with gentamicin can reduce postoperative inflammatory factors of esophageal cancer patients, and promotes the recovery of respiratory function without increasing the incidence of ADR.
期刊: 2017年第28卷第9期
编辑: 王亮,谷席娟,李金博,李辉
AUTHORS: WANG Liang,GU Xijuan,LI Jinbo,LI Hui
关键字: 氨溴索;庆大霉素;雾化吸入;食管癌;呼吸功能;炎症因子
KEYWORDS: Ambroxol; Gentamicin; Aerosol inhalation; Esophageal cancer; Respiratory function; Inflammatory factor
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