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胺碘酮联合缬沙坦治疗老年阵发性心房颤动的临床观察
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篇名: 胺碘酮联合缬沙坦治疗老年阵发性心房颤动的临床观察
TITLE:
摘要: 目的:观察胺碘酮联合缬沙坦治疗老年阵发性心房颤动(房颤)的疗效和安全性。方法:130例老年阵发性房颤患者随机均分为对照组和观察组。对照组患者给予胺碘酮片第1周0.6 g,口服,每日3次,第2周0.4 g,口服,每日2次,第3周0.2 g,口服,每日2次;观察组患者在对照组治疗的基础上加用缬沙坦胶囊第1~3天0.4 g,口服,每日1次,3 d后若患者未出现低血压则剂量增加至0.8 g,口服,每日1次,若患者血压低于100/60 mm Hg,则剂量减至0.4 g,口服,每日1次。两组患者疗程均为12周。观察两组患者的临床疗效,治疗前后左心房内径(LA)、左心室舒张末期容量(LVEDV)、左心室收缩末期容量(LVESV)、左心射血分数(LVEF)、心率、心胸比、收缩压、舒张压及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者LA、LVEDV、LVESV、心率、心胸比、收缩压、舒张压均显著低于同组治疗前,且观察组低于对照组, LVEF显著高于同组治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:胺碘酮联合缬沙坦治疗老年阵发性房颤较单用胺碘酮疗效更显著,安全性相当。
ABSTRACT: OBJECTIVE: To observe the efficacy and safety of amiodarone combined with valsartan in the treatment of paroxysmal atrial fibrillation in elderly patients. METHODS:130 elderly patients with paroxysmal atrial fibrillation were randomly divided into observation and control group. Control group was orally given Amiodarone tablet 0.6 g in the first week, 3 times a day, 0.4 g in the second week, twice a day, 0.2 g in the third week, twice a day; observation group was additionally given valsartan capsule 0.4 g in the first 1-3 day(s), once a day, the dose was increased to 0.8 g if patients showed no hypotension, once a day, and then decreased to 0.4 g if the pressure was lower than 100/60 mm Hg, once a day. The treatment course for both groups was 12 weeks. Clinical efficacy, and left atrium (LA), left ventricular end-diastolic volume(LVEDV), left ventricular systolic volume (LVESV), left ventricular ejection fraction (LVEF), heart rate, cardiothoracic ratio, systolic blood pressure, diastolic blood pressure before and after treatment, and incidence of adverse reactions in 2 groups were observed. RESULTS: Total effective rate in observation group was significantly higher than control group, the difference was statistically significant(P<0.05). After treatment, LA, LVEDV and LVESV, heart rate, cardiothoracic ratio, systolic blood pressure, diastolic blood pressure in 2 groups were significantly lower than before, and observation group was lower than control group, LVEF was significantly higher than before, and observation group was higher than control group, the differences were statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions(P>0.05). CONCLUSIONS:The efficacy of amiodarone combined with valsartan is more obvious than only amiodarone in the treatment of paroxysmal atrial fibrillation in elderly patients, with similar safety.
期刊: 2015年第26卷第36期
编辑: 王桂萍,方伟钧,潘锋君,王琳青
AUTHORS: WANG Gui-ping,FANG Wei-jun,PAN Feng-jun,WANG Lin-qing
关键字: 胺碘酮;缬沙坦;阵发性房颤;疗效;安全性
KEYWORDS: Amiodarone; Valsartan; Paroxysmal atrial fibrillation; Efficacy; Safety
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