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某基层医院超说明书用药情况的横断面调查
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篇名: 某基层医院超说明书用药情况的横断面调查
TITLE:
摘要: 目的:为促进临床合理用药提供参考。方法:采用横断面调查方法,对我院2014年6月19日所有住院及门诊患者的住院医嘱(489份)、门诊处方(466份)中出现的超说明书用药情况进行统计分析。结果:调查当天我院住院、门诊的超说明书用药医嘱条目数及比率分别为240、14.1%(240/1 704)和149、17.4%(149/852)。超说明书用药类型方面,改变给药频次、改变适应证、改变注射液配伍浓度、改变给药剂量排前4位。结论:超说明书用药有些属于合理用药,有各类指南、专家共识及文献报道支撑;有些属于不合理用药,临床应避免这类不合理用药,药师审方时应严格把关。同时,建议药品生产企业及时更新药品说明书,为保障患者用药安全提供依据。
ABSTRACT: OBJECTIVE: To provide reference for the clinical rational drug use. METHODS:Cross-sectional survey was adopted to statistically analyze the off-label use of inpatient (489 prescriptions) and outpatient prescriptions(466 prescriptions) in our hospital in Jun. 19, 2014. RESULTS: The prescription items and ratios of off-label use in inpatients and outpatients in our hospital were 240, 14.1% (240/1 704) and 149, 17.4%(149/852), respectively. The top 4 types of drug off-label use included changing administration frequency, indications, compatibility concentrations of injections and dosage. CONCLUSIONS: Some of off-label use are rational, supporting by kinds of guidelines, expert consensus and literature reporting; while some are irrational, clinic should avoid this kind of irrational use and be strictly controlled by pharmacists. Meanwhile, it is suggested that the drug manufacturers update the instructions timely to provide reference for ensuring safety drug use of patients.
期刊: 2015年第26卷第36期
编辑: 王丽华
AUTHORS: WANG Li-hua
关键字: 基层医院;药品说明书;超说明书用药;横断面调查
KEYWORDS: Primary hospital; Drug package inserts; Drug off-label use; Cross-sectional survey
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