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郁金4种基源饮片的止痛作用及其水提物中莪术烯醇含量的比较研究
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篇名: 郁金4种基源饮片的止痛作用及其水提物中莪术烯醇含量的比较研究
TITLE: Study on Analgesic Effect of 4 Sources of Curcumae Radix Decoction Pieces and Comparison of Curcuminol Content in Its Water Extracts
摘要: 目的:研究郁金药材4种基源饮片[温郁金、广西莪术(桂郁金)、蓬莪术(绿丝郁金)、姜黄(黄丝郁金)]的止痛作用,比较其水提物中莪术烯醇含量。方法:以阿司匹林为阳性对照药物,使用醋酸扭体法考察郁金4种基源饮片水提液对小鼠扭体潜伏期和扭体次数的影响。按照2015年版《中国药典》(四部)中的“烘干法”测定郁金4种基源饮片(每种基源10批,下同)的水分得率。使用热浸法考察郁金4种基源饮片水提物得率,采用高效液相色谱法测定其水提物中莪术烯醇含量;并进行比较。结果:与模型组比较,阿司匹林和郁金4种基源饮片水提液均能显著延长模型小鼠的扭体潜伏期,温郁金水提液和绿丝郁金水提液还能显著减少模型小鼠的扭体次数(P<0.05或P<0.01)。温郁金、桂郁金、绿丝郁金、黄丝郁金的水分含量分别为7.39%~8.80%、7.88%~9.88%、7.66%~9.86%、7.68%~10.20%,水提物平均得率分别为46.30%、60.40%、38.65%、42.99%,水提物中莪术烯醇平均含量分别为0.271、0.066、0.310、0.058mg/g。除个别批次外,郁金同种基源饮片的水提物得率越高,莪术烯醇含量也越高。结论:郁金4种基源饮片均有止痛作用,温郁金与绿丝郁金中莪术烯醇含量相近,桂郁金和黄丝郁金中莪术烯醇含量约为绿丝郁金、温郁金的1/5。
ABSTRACT: OBJECTIVE:To study the analgesic effects of 4 sources of Curcumae Radix decoction pieces (Curcuma wenyujin , C. kwangsiensis ,C. phaeocaulis and C. longa ),and compare the contents of curcumenol in their water extracts. METHODS : Using aspirin as positive control ,acetic acid writhing method was used to investigate the effects of 4 sources of Curcumae Radix decoction pieces water extract on writhing latency and times of writhing in mice. The moisture contents of 4 sources of Curcumae Radix decoction pieces (10 batches of each source ,the same below )were determined according to the drying method in 2015 edition of Chinese Pharmacopoeia (part Ⅳ). The yield of water extract in 4 sources of Curcumae Radix decoction pieces were investigated by hot dipping method ,the contents of curcumenol in water extract of 4 sources of Curcumae Radix decoction pieces were determined by HPLC ,and comparison was conducted. RESULTS :Compared with model group ,aspirin and water extracts of 4 sources of Curcumae Radix decoction pieces could significantly prolong the writhing latency of model mice ,and the water extracts of C. wenyujin and C. phaeocaulis could significantly reduce the writhing times of model mice (P<0.05 or P<0.01). For C. wenyujin ,C. kwangsiensis ,C. phaeocaulis and C. longa ,the contents of moisture were 7.39%-8.80%,7.88%-9.88%,7.66%- 10.5468/ogs.2019.62.6.382 9.86% and 7.68%-10.20%;the average yield of water extract were 46.30%,60.40%,38.65%,42.99%;the average contents of curcumenol in water extract were 0.271,0.066,0.310,0.058 mg/g. Except for a few batches ,the higher the yield of water extract,the higher the content of curcuminol in the same source of Curcumae Radix decoction pieces. CONCLUSIONS :Four sources of Curcumae Radix decoction pieces have analgesic effect. The contents of curcumenol in C. wenyujin and C. phaeocaulis were similar ,and the contents of curcumenol in C. kwangsiensis and C. longa about 1/5 of that in C. phaeocaulis and C. wenyujin .
期刊: 2020年第31卷第18期
编辑: 石典花,苏本正,张军,戴衍朋
AUTHORS: SHI Dianhua ,SU Benzheng ,ZHANG Jun,DAI Yanpeng
关键字: 郁金饮片;不同基源;止痛作用;莪术烯醇;含量比较
KEYWORDS: Curcumae Radix decoction pieces ;Different sources ;Analgesic effect ;Curcumenol;Content comparison
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