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我院2012-2015年鲍曼不动杆菌分布及耐药性分析
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篇名: 我院2012-2015年鲍曼不动杆菌分布及耐药性分析
TITLE:
摘要: 目的:了解我院鲍曼不动杆菌的分布及耐药性,为合理使用抗菌药物提供参考。方法:收集我院2012年1月-2015年12月住院患者送检的各类临床标本,采用VITEK-2微生物分析仪对分离出的鲍曼不动杆菌进行鉴定及药敏试验;统计我院住院患者抗菌药物使用率及多重耐药、泛耐药鲍曼不动杆菌的检出情况,采用Pearson相关性分析考察两者的相关性。结果:我院2012-2015年共分离出鲍曼不动杆菌2 468株,主要来源于痰液标本(88.2%),主要分布于呼吸内科(47.0%)及重症监护病房(13.1%)。鲍曼不动杆菌对常见抗菌药物的耐药率总体较高,仅对替加环素敏感。我院各年度分别检出多重耐药鲍曼不动杆菌386(79.3%)、434(61.6%)、358(53.4%)和291(48.0%)株,泛耐药鲍曼不动杆菌336(69.0%)、385(54.7%)、331(49.3%)和256(42.2%)株。我院各年度抗菌药物使用率分别为56.7%、50.8%、45.0%和42.8%。多重耐药、泛耐药鲍曼不动杆菌在其总株数中的比例与抗菌药物使用率均呈正相关(r分别为0.987、0.981,P<0.05)。结论:鲍曼不动杆菌是我院重要的院内感染病原菌,以引起呼吸系统感染为主;该菌的耐药现状不容乐观,替加环素可作为鲍曼不动杆菌感染治疗的首选药物之一。我院应继续严格控制抗菌药物的使用,减缓耐药菌株产生。
ABSTRACT: OBJECTIVE: To investigate the distribution and drug resistance of Acinetobacter baumannii  in our hospital, and provide reference for rational use of antibiotics. METHODS: Clinical specimen of inpatients in our hospital from Jan. 2012 to Dec. 2015 was collected, the identification of strains and drug sensitivity test were performed by the VITEK-2 microorganism analyzer; use rate of antibiotics and detection of multidrug-resistant and pandrug-resistant A. baumannii  for inpatients in our hospital were analyzed, and their correlation was detected by Pearson correlation analysis. RESULTS: Totally 2 468 strains of A. baumannii  were isolated in our hospital during 2012-2015, mainly derived from sputum samples (88.2%), distributed in respiratory medicine department (47.0%) and ICU (13.1%); A. baumannii  showed totally high drug resistance to common antibiotics, and only sensitive to tigecycline. Totally 386 (79.3%), 434 (61.6%), 358 (53.4%) and 291 (48.0%) strains multidrug-resistant A. baumannii were detected every year in our hospital; and pandrug-resistant A. baumannii  were 336 (69.0%), 385 (54.7%), 331 (49.3%) and 256 (42.2%) strains, respectively. There was a positive correlation between the percentage of multidrug-resistant and pandrug-resistant A. baumannii in total strains and use rate of antibiotics (r=0.987、0.981,P<0.05). CONCLUSIONS: A. baumannii has emerged as an important pathogen in hospital acquired infections, which mainly caused respiratory system infection; the drug resistance situation is not optimistic, tigecycline can be used as one of the best choice for treatment of A. baumannii  infections; our hospital should continue to control the use of antibiotics to decrease the emerging of drug resistance strains.
期刊: 2016年第27卷第26期
编辑: 黄亚建,陈嘉纬,郭旭光,司徒冰
AUTHORS: HUANG Yajian,CHEN Jiawei,GUO Xuguang,SITU Bing
关键字: 鲍曼不动杆菌;分布;多重耐药;泛耐药;抗菌药物;耐药性
KEYWORDS: Acinetobacter baumannii; Distribution; Multidrug-resistant; Pandrug-resistant; Antibiotics; Drug resistance
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